What if the real secret to aging well isn’t found in a futuristic lab, but in understanding your body more honestly than you ever have before?

From the very first question, this conversation challenges the assumptions most of us carry about health, longevity, and what it means to “measure” how well we’re aging. Instead of getting lost in the noise of biological clocks, trends, and high-priced diagnostics, Julian, Andrea, and Matt bring everything back to practical, evidence-backed fundamentals, the kind of markers any person can track, understand, and actually do something about. It’s a refreshing look at why knowing your sleep patterns, blood pressure, daily habits, and cognitive health may be more powerful than any shiny longevity product marketed today.

Andrea Maier is a leading geriatrician focused on improving health span through practical, evidence-based approaches, and Matt Kaeberlein is a renowned longevity researcher exploring the biology of aging and interventions to extend healthy life.

Their focus shifts to the future: personalized medicine, repurposed therapies, the role of AI, and the growing public demand for accessible, trustworthy health guidance. The ideas here don’t promise magic fixes or miracle pills; instead, they offer a roadmap for making better decisions, understanding your own data, and appreciating how much your daily environment shapes your long-term well-being. It’s an honest, grounded, and deeply encouraging exploration of how anyone can start improving their health span, no matter where they’re starting from.

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What You’ll Learn

• How to measure your biological age accurately

• Which lifestyle habits actually improve longevity

• Why some supplements work and many don’t

• How to use wearables without being misled by the data

• What truly drives aging and how to slow it down

• How advanced therapeutics fit into longevity (and where they don’t)

• Why a guided, evidence-based approach beats self-experimentation

• How better sleep and stress management impact long-term health

  
  

⏱ Timestamps

00:43 Bringing Science Into the Business of Longevity

02:12 Why Longevity Research Has More to Offer Than We Think

03:51 Imagining the Future of Longevity Medicine

05:12 How to Accurately Measure Your Biological Age

08:26 Why Whatever You Measure Should Also Be Fun

10:04 Making Lifestyle Interventions Appealing (and Effective)

12:09 Understanding Biological Differences Across Individuals

14:16 What Counts as an Advanced Therapeutic?

17:15 Aging Happens Constantly — Here’s What That Means

19:50 The Formula Behind a Proper Longevity Treatment Plan

23:35 Why Not All Supplements Work Well Together

25:48 A Guided, Smarter Approach to Testing

28:30 Snake Oil: Harmful, Harmless, or Helpful?

32:06 Why Good Sleep Might Be Your Strongest Health Tool

34:37 The Accuracy Problem With Digital Health Monitors

40:48 The Real Purpose of Wearable Health Devices

45:48 What Breakthroughs Are Coming Next in Longevity

47:17 Shifting Toward a Proactive Health Mindset

52:00 The Challenge of Accessing High-Quality Testing

53:18 How to Slow Down Aging in Practical Ways

🎙 Hosted by Julian Issa

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Episode Resources:

Andrea Maier

LinkedIn: https://sg.linkedin.com/in/andreamaierprof 

X: https://x.com/AndreaBMaier 

Instagram: https://www.instagram.com/drandreamaier 

Matt Kaeberlein

LinkedIn: https://www.linkedin.com/in/mkaeberlein 

X: https://x.com/mkaeberlein 

Instagram: https://www.instagram.com/mkaeberlein 

YouTube: https://www.youtube.com/@optispan 

TikTok: https://www.tiktok.com/@optispan