The Truth About Lean Mass Hyper Responders and Keto
Update: 2025-09-17
Description
In this episode of Functional Medicine Foundations, host Amber Warren, PA-C, sits down with Dr. Mark Holthouse, MD, IFMCP, to unpack the controversial topic of lean mass hyper responders and the surprising findings of the new KETO-CTA trial. They explain why some people see skyrocketing LDL cholesterol and ApoB levels on a low-carb diet, what this means for cardiometabolic health, and how study design can sometimes hide the real risks.
You’ll learn:
• Who qualifies as a lean mass hyper responder
• Why high cholesterol still matters, even in fit, keto-adapted people
• The role of gut health, fiber, and the microbiome in protecting your heart
Whether you’re passionate about keto, carnivore, or functional medicine, this conversation gives you clarity on the science—and tools to protect your long-term health.
You’ll learn:
• Who qualifies as a lean mass hyper responder
• Why high cholesterol still matters, even in fit, keto-adapted people
• The role of gut health, fiber, and the microbiome in protecting your heart
Whether you’re passionate about keto, carnivore, or functional medicine, this conversation gives you clarity on the science—and tools to protect your long-term health.
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