Bioconjugation of antibodies to drugs via chemical linkers is how antibody drug conjugates (ADCs) are made. We’re joined by Matt Giese, Senior Scientist at Vector Laboratories, who talks us through the complex chemistry options and biodesign considerations that have to be considered and balanced when making a successful ADC.

How does one build the skillset to work in biodesign of ADCs you might ask? Well, Matt’s career path might not provide a clearcut roadmap like you might hope. That’s because Matt started his career as an auto mechanic, moved into art, went back to auto mechanics, worked as baggage handler and as a construction worker, all before ever finding chemistry. If you think that’s a convoluted path, just wait to hear about his academic and professional work journeys.  

You’ll revel in following this journey, and in the lessons and diverse skills learned along the way. Join us to hear it yourself, from who might just be the most interesting man in chemistry!

Related episodes:

• Season 5, Ep.7: The life-altering impact of one chemist’s sabbatical
• Season 2, Ep.1: Chemistry: a modern American dream
• Season 3, Ep.5: On the COVID pill and other process chemistry tales

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