In this episode, we dive deep into the latest research from late 2025 and explore the exploding field of Psychophysiology. We look at how Heart Rate Variability (HRV) is becoming the "master key" for detecting everything from complex emotions to psychosis. We also break down a massive new study on how antidepressants shift your physical metabolism, the effectiveness of "light-guided" breathing for office stress, and how VR gaming affects your autonomic nervous system.

Links & Resources Mentioned:

Clinical Psychiatry & Pharmacology

• Article: Which Antidepressants Shift Physiology? (Conexiant)
  
  
  • Takeaway: A look at how different antidepressant classes impact weight, blood pressure, and heart rate.
  
  



• Paper: Reducing Artifact Preprocessing in HRV-Based Personalized Psychosis Prediction (World Scientific)
  
  
  • Takeaway: Using AI to predict psychosis directly from wearable data.
  
  

Breathing & Interventions

• Paper: Light-guided resonant breathing enhances psychophysiological stress recovery in a simulated office environment (Nature Scientific Reports)


• Paper: Resonant breathing in hospitalised psychiatric patients with persistent somatic symptoms (General Psychiatry / BMJ)

The Science of Stress & Emotion (HRV)

• Paper: Measures of the psychophysiological response to recurrent anticipatory stress - the influence of neuroticism (Nature Scientific Reports)


• Paper: Heart rate variability reveals graded task difficulty effects and sensitization dynamics (Springer / J. Physiol. Anthropol.)


• Paper: HRV-Based Recognition of Complex Emotions: Feature Identification (MDPI Healthcare)

Physiology in Action (VR & Exercise)

• Paper: Impact of Stereoscopic Technologies on Heart Rate Variability in Extreme VR Gaming Conditions (MDPI Technologies)


• Paper: A controlled comparative study on the effect of arterial occlusion pressure on immediate sympathetic responses (Nature Scientific Reports)