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Virus Biodiversity: Mutation, Genetic Differences, Selection, Propagation, Disease

Virus Biodiversity: Mutation, Genetic Differences, Selection, Propagation, Disease

Update: 2014-08-08

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Evolution of RNA viruses occurs according to their high mutation rates that generate complex genetically heterogeneous populations referred to as quasispecies. The large collection of quasispecies leads to natural selection with elimination of noncompetitive (inferior) genomes and enhancement of superior genomes by fitness. Importantly, dissecting the persistent infection caused by mutation and selection of LCMV Cl 13 has illuminated mechanistically how human viral infections like HIV, HCV, and HBV persist.

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Virus Biodiversity: Mutation, Genetic Differences, Selection, Propagation, Disease

Virus Biodiversity: Mutation, Genetic Differences, Selection, Propagation, Disease

Michael B. A. Oldstone, M.D.