The paper presents Celera Genomics' work on human genome sequencing, detailing its methods, including shotgun sequencing and genome assembly. The process of building DNA libraries, data analysis, and assembly strategy is described, using two independent approaches. The paper also discusses gene prediction, identification of single nucleotide polymorphisms (SNPs), and a comparison with other eukaryotic genomes, highlighting expansions of human-specific protein families. Finally, an overview of the predicted genes and their involvement in complex biological processes is offered.

Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., ... & Waterston, R. H. (2001). The sequence of the human genome. Science, 291(5507), 1304-1351.