Week 4 in fantasy football has seen some major injury and return news that is reshuffling the rankings for managers everywhere. ESPN reports that CeeDee Lamb, star receiver for Dallas, suffered a high ankle sprain. Todd Archer from ESPN says Lamb might be out for three to four weeks, which significantly downgrades quarterback Dak Prescott’s ceiling and boosts tight end Jake Ferguson, who hauled in 12 catches last week, making him close to a top-10 TE option until Lamb returns. George Pickens also gets a bump and is now viewed as a solid WR2.

Xavier Worthy is making headlines for the Kansas City Chiefs. Starting the season with a dislocated shoulder and labral tear, Worthy took the rehab route and, according to ESPN's Stephania Bell, is off the injury report and fully practiced this week. Fantasy managers are eager to see if he’s back to form, but there’s always the risk of aggravation considering his injury's seriousness, so expectations should be tempered.

San Francisco’s wide receiver Ricky Pearsall joined the injury report midweek with knee soreness, but both Pearsall and coach Kyle Shanahan said he could have played if needed and plan is to rest him for the length of the season. With top pass catchers like Brandon Aiyuk and George Kittle still out, Pearsall holds considerable fantasy value for now.

The Commanders’ Terry McLaurin is a risk this week due to a quad injury sustained in the third quarter last weekend. Coach Dan Quinn said McLaurin is seeking a second opinion, something that's fairly common but does add some uncertainty for fantasy lineups. If McLaurin misses time, all Commanders receivers get a downgrade.

Arizona running back James Conner went down with a serious-looking lower leg injury. ESPN’s Adam Schefter reports it will likely require surgery, with no current timetable for his return. This creates an opportunity for the Cardinals’ backup running backs, but given the team’s offensive struggles, expectations should be managed.

Najee Harris, now with the Chargers, suffered an Achilles injury last week. Coach Jim Harbaugh told reporters that the early indication is season-ending. This likely means a significant increase in value for the backup Los Angeles backs and a hit to Harris’ dynasty stock.

Quarterback changes are another big storyline: The 49ers get Brock Purdy back after missing two games, according to Sports Illustrated. This slightly upgrades the other San Francisco skill players as Purdy is an upgrade from Mac Jones. Meanwhile, Washington’s Jayden Daniels will miss another week with a knee injury and Marcus Mariota gets the start. That’s a downgrade for all Washington pass catchers per SI.

ESPN and FantasyPros are advising listeners to watch for any last-minute surprises when inactives are announced shortly before kickoff, as other injuries are still being monitored, including Houston’s Nico Collins and Baltimore’s Isaiah Likely.

With these updates, fantasy managers are reminded to check injury updates and actives lists right up until game time to get an edge. Every week, injuries and returns—even for one week—shake up the landscape, and even top options can quickly fall out of favor.

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