47. Do You Need A Statin?

Update: 2025-11-21

Description

In this episode of Walk, Don't Run to the Doctor, we take a deep dive into statins, their true benefits, their real risks, and the massive role lifestyle plays in shaping heart disease outcomes. Rather than accepting oversimplified medical advice, this episode empowers you to think critically, understand uncertainty in medicine, and make fully informed decisions about your own health. You'll learn how to interpret risk statistics (like relative vs absolute risk), why lifestyle may outperform medication for many people, and why statins are helpful for some—yet potentially unnecessary or harmful for others. If you've ever been told "your cholesterol is high, you need a statin," this episode will give you the tools to ask better questions and understand whether that advice truly applies to someone like you.

Key Takeaways:

-Medical uncertainty is real — many "facts" are actually opinions without solid or applicable evidence.

-Statins help some people more than others: -Strong evidence for people who already had a heart attack.

-Much smaller benefit (sometimes minimal) for healthy, active people without prior heart disease.

-Absolute vs. relative risk matters: -A "25% reduction in risk" may really mean only 1 fewer event per 100 people.

-Lifestyle changes can reduce risk by 50–80%, often outperforming statin benefits—especially for people who exercise, eat whole foods, avoid smoking, keep weight down, and drink moderately.

-Statin risks are real: Muscle pain: up to 1 in 10 Diabetes risk increased: about 1 in 200 Possible cognitive impairment (enough for an FDA warning) Polypharmacy (multiple medications) increases uncertainty and side-effect risks.

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Check out this video on Completely Rethinking the Link Between Statins, Cholesterol, & Heart Disease, w/ Dr. Aseem Malhotra: https://www.youtube.com/watch?v=-RU3Ouxt1vs&t=251s

References from today's podcast:

Ioannidis J. P. (2005). Why most published research findings are false. PLoS medicine, 2(8), e124. https://doi.org/10.1371/journal.pmed.0020124

Luo, Y., Liu, J., Zeng, J., & Pan, H. (2024). Global burden of cardiovascular diseases attributed to low physical activity. American journal of preventive cardiology, 17, 100633. https://doi.org/10.1016/j.ajpc.2024.100633

Ye, Z., Det al. (2025). Association of statins use and genetic susceptibility with incidence of Alzheimer's disease. The journal of prevention of Alzheimer's disease, 12(2), 100025. https://doi.org/10.1016/j.tjpad.2024.100025

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