This podcast from the International Emergency Medicine Education Project details the approach to managing acutely agitated patients, focusing on differentiating organic from inorganic (psychiatric) causes. It outlines a systematic approach encompassing history taking, physical examination (emphasizing ABCDE assessment), diagnostic testing (including hematology, urine, and imaging), and management strategies (both pharmacological and non-pharmacological). The podcast also emphasizes a holistic biopsychosocial model for managing psychosis, covering immediate, intermediate, and long-term care. Specific medications and their usage are discussed, along with diagnostic criteria for various psychotic disorders. Finally, the podcast provides guidance on when to admit a patient.