This podcast from the International Emergency Medicine Education Project focuses on the diagnosis and management of delirium, a serious condition characterized by confusion and altered mental status. It details the clinical presentation of delirium, differentiating it from dementia, depression, and psychosis, and explores various causes using mnemonics. Diagnostic tools like the Confusion Assessment Method (CAM) and CIWA-R are explained, alongside treatment approaches including medication and environmental modifications. Specific management strategies for alcohol withdrawal delirium and delirium in elderly and pediatric patients are also addressed. The podcast ultimately emphasizes the importance of prompt diagnosis and intervention to improve patient outcomes.