BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems

Update: 2007-10-30

Description

Outline:Introduction and overviewSome of the advantages of therapeutic genesSome of the advantages of molecular biosensor feedback control systemsWhy a nanodelivery approach is appropriateThe therapeutic gene approachWhat constitutes a "therapeutic gene" ?Transient versus stable expression modesMolecular feedback control systemsDrug delivery has traditionally not used feedback controlsWhy feedback control might be a very good idea!Positive or negative feedback?Molecular Biosensors as a component of a nanomedicine feedback control systemWhat is a molecular biosensor?How a molecular biosensor functions as a therapeutic gene switchBuilding integrated molecular biosensor/gene delivery systems –some examplesRequired componentsExample of a ribozyme/antivirus systemExample of an ARE biosensor/DNA repair system

Comments

In Channel

BME 695N Lecture 19: In vivo model systems to study nanomedical approaches to cancer detection and intervention

2007-11-27--:--

BME 695N Lecture 21: FDA and EPA Regulatory Issues

2007-11-27--:--

BME 695N Lecture 20: GMP and issues of quality control manufacture of nanodelivery systems

2007-11-15--:--

BME 695N Lecture 18: Designing nanodelivery systems for in-vivo use

2007-11-12--:--

BME 695N Lecture 17: Assessing nanotoxicity at the single cell level

2007-11-06--:--

BME 695N Lecture 16: Assessing drug efficacy at the single cell level

2007-11-02--:--

BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems

2007-10-30--:--

BME 695N Lecture 14: Challenges of proper drug dosing with nanodelivery systems

2007-10-29--:--

BME 695N Lecture 13: Assessing Zeta Potentials

2007-10-29--:--

BME 695N Lecture 12: Introduction to X-ray Photoelectron Spectroscopy and the Examples of Biologically-Relevant Applications

2007-10-19--:--

BME 695N Lecture 11: Construction of biomolecule conjugated nanoparticles

2007-10-01--:--

BME 695N Lecture 9: Atomic Force Microscopy (AFM) for Nanomedical Systems (cells and nanoparticles)

2007-10-01--:--

BME 695N Lecture 6: Rare-event targeting of cells in-vitro and in-vivo

2007-09-26--:--

BME 695N Lecture 10: Nanomaterials for core design

2007-09-26--:--

BME 695N Lecture 8: Technologies for measuring nanomedical systems on/within cells

2007-09-24--:--

BME 695N Lecture 7: Normal & facilitated cell entry mechanisms

2007-09-16--:--

BME 695N Lecture 5: Cell Targeting

2007-09-12--:--

BME 695N Lecture 4: Designing "Theragnostic" Systems

2007-09-04--:--

BME 695N Lecture 3: Overview of Basic Nanomedical Systems Design

2007-08-29--:--

BME 695N Lecture 2: Basic Concepts of Nanomedical Systems

2007-08-28--:--

00:00

BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems

#box-pro-ellipsis-176069017595563{-webkit-line-clamp:2;}BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems

BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems

James Leary

BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems