The role of coherence in quantum thermodynamics has been extensively studied in the recent years and it is now well-understood that coherence between different energy eigenstates is a resource independent of other thermodynamics resources, such as work. A fundamental remaining open question is whether the laws of quantum mechanics and thermodynamics allow the existence a "coherence distillation machine", i.e. a machine that, by possibly consuming work, obtains pure coherent states from mixed states, at a nonzero rate. This question is related to another fundamental question: Starting from many copies of noisy quantum clocks which are (approximately) synchronized with a reference clock, can we distill synchronized clocks in pure states, at a non-zero rate? In this paper we study quantities called "coherence cost" and "distillable coherence", which determine the rate of conversion of coherence in a standard pure state to general mixed states, and vice versa, in the context of quantum thermodynamics. We find that the coherence cost of any state (pure or mixed) is determined by its Quantum Fisher Information (QFI), thereby revealing a novel operational interpretation of this central quantity of quantum metrology. On the other hand, we show that, surprisingly, distillable coherence is zero for typical (full-rank) mixed states. Hence, we establish the impossibility of coherence distillation machines in quantum thermodynamics, which can be compared with the impossibility of perpetual motion machines or cloning machines. To establish this result, we introduce a new additive quantifier of coherence, called the "purity of coherence", and argue that its relation with QFI is analogous to the relation between the free and total energies in thermodynamics.