Join us on the ERCM Medicine Podcast for a conversation with John R. Adler Jr., MD, the visionary inventor of the CyberKnife and founder of Zap-X. As a Stanford professor, Dr. Adler has revolutionized neurosurgery through the development of robotic radiosurgery systems.

He shares his extraordinary journey – from being inspired by Lars Leksell at the Karolinska Institute in Stockholm to founding two groundbreaking medical technology companies. He speaks candidly about daily setbacks, the skepticism of colleagues (who initially called the CyberKnife „Adler's Folly“), and why persistence is the key to success.

His provocative message to young innovators: „Don't do it – unless you're prepared to never give up.“ This episode provides an honest assessment of the challenges in translating medical innovations into clinical practice.

Key Topics:

• Innovation vs. Reality: Why most inventions fail
• CyberKnife Development: From initial idea to market success
• Radiosurgery as a surgical tool: Precision without cutting
• ZapX: The next generation of specialized radiosurgery
• Medical resistance: Why some neurosurgeons resist modern technologies

Der ERCM Medizin Podcast – Social & Website:Instagram: @ercm.podcastTikTok: @ercm.podcastWebsite: www.erc-munich.comContact: podcast@erc-munich.comJohn R. Adler Jr., MD:Website: https://zapsurgical.com/About: https://en.wikipedia.org/wiki/John_R._Adler LinkedIn: https://www.linkedin.com/in/john-adler-1875b95/

Timestamps:00:00 - Intro02:19 - From Karolinska fellowship to the CyberKnife idea04:46 - The biggest hurdles in the early years06:31 - Persisting despite daily setbacks08:12 - From academic to entrepreneur10:18 - CyberKnife success wasn't enough: The ZapX vision13:37 - Radiosurgery as a neurosurgical tool16:18 - Resistance in the neurosurgery community18:09 - Advice for young innovators: "Don't do it"20:04 - Legacy and unfinished work21:58 - The future of radiosurgery

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