EB. 137: What REALLY Causes Glycation (Is Sugar Really the Problem?)
Description
Why glucose and fructose are not the primary drivers of AGE formation
Whether blood sugar spikes cause glycation
How fats and ketones can cause glycation
What’s really responsible for glycation in type 2 diabetes
Whether fructose causes more glycation than glucose
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Click here to check out the show notes:
https://www.jayfeldmanwellness.com/eb-137-what-really-causes-glycation-is-sugar-really-the-problem/
Timestamps:
0:00 – intro
0:46 – common beliefs about carbohydrates and glycation
2:35 – what are glycation and advanced glycation end products?
6:57 – the process of glycation from glucose
9:30 – is sugar the only source of AGEs?
15:00 – primary drivers of glycation: dicarbonyls
19:30 – how fatty acids, amino acids, and ketones cause AGE formation
21:23 – how increased gluconeogenesis on low-carb diets increases AGE formation
22:53 – glucose metabolism produces very few glycation products in the context of a healthy metabolism
25:33 – omega-6s form AGEs more than 10x faster than glucose
28:24 – the role of ALEs (advanced lipoxidation end products) in glycation and chronic disease
30:36 – whether blood sugar spikes cause glycation
38:52 – whether fructose causes more glycation (or fructation) than glucose
47:05 – can glycation from fructose (fructation) be measured, and does this matter?
52:06 – problems with research looking at fructose’s AGE formation in animal models
United States
