Episode 022 - The Energize Breakdown: Mitochondria, Protein Stress, and Broken Fuel Signals
Description
Feeling tired but wired—even when you sleep, eat clean, and try to do everything right?
In this episode, Brandon maps the **Energize** domain: how mitochondria, protein stress, and broken fuel signals create fatigue long before labs go “abnormal.” You’ll learn how to rebuild energy by restoring **signal trust**, not just adding more effort.
What we cover:
• Signals vs. fuel: why you can feel drained with plenty of stored energy
• Mitochondria as **sensors**, not just engines—fusion, fission, mitophagy 101
• Protein stress (proteotoxic load): misfolded proteins, chaperones, autophagy, proteasome
• Broken fuel sensing: AMPK ↔ mTOR, insulin sensitivity, metabolic flexibility
• Real‑life signs of Energize drift (cravings, post‑meal crashes, poor recovery)
• A practical rebuild: circadian rhythm first; then mitochondrial nutrients (Mg, B‑complex, CoQ10, carnitine, NAC, ALA, astaxanthin, ergothioneine, butyrate);
fuel flexibility (30g protein AM + fiber, movement after meals); and training that builds capacity, not depletion
• Quick starts: morning light; delay caffeine 60–90 min; breakfast protein or a **BIOMEnd® + fiber** shake if appetite is low
🎯 Take the Drift Quiz: https://www.themetaboliccompass.com/quiz
➡️ Next: Episode 023 — The Strengthen Breakdown: Repair, Defense, and Why Your Body Gets “Stuck” in Maintenance
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