Episode 024 - The Withdraw Breakdown: Autophagy, Epigenetics, and Cellular Static
Description
When your biology is overwhelmed, it doesn’t always crash—it clogs.
In this episode, Brandon breaks down the **Withdraw** domain: epigenetic alterations, disabled macroautophagy, and altered intercellular communication—why they’re the quiet source of brain fog, flat mood, and ‘clogged’ recovery—and how to restore clarity without overcorrecting.
What we cover:
• What Withdraw drift feels like (foggy but wired, numb but inflamed)
• Epigenetic alterations: reading the wrong ‘pages’ and how to retune expression
• Disabled macroautophagy: the cellular cleanup crew goes offline
• Altered intercellular communication: hormonal/immune/static between cells
• Practical restore plan: fasting-mimicking rhythms, polyphenols (EGCG/quercetin/curcumin), bile/lymph flow, circadian sleep, HRV downshifts
• Why sequence matters (Nurture/Energize/Strengthen set the stage for Withdraw)
🎯 Take the Drift Quiz: https://www.themetaboliccompass.com/quiz
➡️ Next: Episode 025 — Rebuilding Nurture When You’re Fried, Fragile, and on Edge
United States
