Explore the critical role of specific blood tests in managing PCOS, focusing on fasting insulin, estradiol, DHEA-S, hs-CRP, and leptin. This episode dives deep into how these tests can guide treatments and lifestyle changes for better health outcomes.

5 KEY TAKEAWAYS

 1. Fasting Insulin as a Foundation: Understanding insulin’s role in PCOS is crucial, as it affects multiple bodily functions and is often elevated in affected individuals.

 2. Importance of Estradiol Levels: Monitoring estradiol is essential for managing PCOS, as it influences ovarian function and overall hormonal balance.

 3. Role of DHEA-S: Elevated levels can indicate adrenal involvement in PCOS, influencing the body’s androgen levels and contributing to symptoms.

 4. Significance of hs-CRP: This inflammatory marker can highlight underlying inflammation associated with PCOS and its impact on cardiovascular health.

 5. Monitoring Leptin: Addresses leptin resistance often seen in PCOS, impacting appetite regulation and metabolic functions.

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TIMESTAMPS

 • 00:00 START

 • 00:01:00 Introduction to PCOS and importance of proactive lab testing.

 • 00:05:00 Detailed discussion on fasting insulin’s role in PCOS.

 • 00:10:00 The critical impact of estradiol and its management.

 • 00:15:00 Exploring DHEA-S and its implications in adrenal health.

 • 00:20:00 Understanding hs-CRP and its link to inflammation.

 • 00:25:00 Leptin’s role in appetite and weight regulation in PCOS.

 • 00:30:00 Summary and key actionable advice on managing PCOS through targeted bloodwork.

RESOURCES

  1. Title: Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277302/

 2. Title: Recent Insights into the Pathophysiology of Polycystic Ovarian Syndrome: A Narrative Review

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832677/

 3. Title: Androgen Excess in Women: Experience with Over 1000 Consecutive Patients

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705998/

 4. Title: The Role of Insulin Resistance in the Polycystic Ovary Syndrome

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676075/

 5. Title: Estrogen Signaling in the Pathobiology of Ovarian Cancer

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830311/

 6. Title: Estrogen and Cardiovascular Disease: Is Timing Everything?

URL: https://pubmed.ncbi.nlm.nih.gov/29224098/

 7. Title: C-Reactive Protein: A Predictive Factor and Marker of Inflammation in Inflammatory Diseases

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647201/

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