Welcome to Cardiology Today – Recorded September 11, 2025. This episode summarizes 2 key cardiology studies on topics like chronic limb-threatening ischemia and infrapopliteal disease. Key takeaway: Fulminant Myocarditis: Predictors of Mortality Defined.

Article Links:

Article 1: Drug-Eluting Resorbable Scaffold Versus Balloon Angioplasty for Below-the-Knee Peripheral Artery Disease: 2-Year Results From the LIFE-BTK Trial. (Circulation)

Article 2: Fulminant myocarditis: outcome predictors in an international cohort study. (European heart journal)

Full episode page: https://podcast.explainheart.com/podcast/fulminant-myocarditis-predictors-of-mortality-defined-09-11-25/

Featured Articles

Article 1: Drug-Eluting Resorbable Scaffold Versus Balloon Angioplasty for Below-the-Knee Peripheral Artery Disease: 2-Year Results From the LIFE-BTK Trial.

Journal: Circulation

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40927852

Summary: The LIFE-BTK trial demonstrated that, at two years, drug-eluting resorbable scaffolds showed no statistically significant difference in the primary patency rate compared to percutaneous transluminal angioplasty in patients with chronic limb-threatening ischemia undergoing infrapopliteal intervention. While scaffold thrombosis was higher in the drug-eluting resorbable scaffold group, major amputation rates were similar between the two groups. This suggests that while the resorbable scaffold does not improve patency, it also does not increase the risk of limb loss.

Article 2: Fulminant myocarditis: outcome predictors in an international cohort study.

Journal: European heart journal

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40928499

Summary: This retrospective study of fulminant myocarditis across 26 European centers identified lymphocytic myocarditis as the most frequent type and revealed distinct clinical courses based on endomyocardial biopsy findings. Predictors of mortality included the need for mechanical circulatory support, particularly extracorporeal membrane oxygenation, and elevated creatinine levels. These findings underscore the importance of early risk stratification and tailored management strategies in fulminant myocarditis.

Transcript

Today’s date is September 11, 2025. Welcome to Cardiology Today. Here are the latest research findings.

Article number one. Drug-Eluting Resorbable Scaffold Versus Balloon Angioplasty for Below-the-Knee Peripheral Artery Disease: 2-Year Results From the LIFE-BTK Trial. The LIFE-BTK trial demonstrated that, at two years, drug-eluting resorbable scaffolds showed no statistically significant difference in the primary patency rate compared to percutaneous transluminal angioplasty in patients with chronic limb-threatening ischemia undergoing infrapopliteal intervention. While scaffold thrombosis was higher in the drug-eluting resorbable scaffold group, major amputation rates were similar between the two groups. This suggests that while the resorbable scaffold does not improve patency, it also does not increase the risk of limb loss.

Article number two. Fulminant myocarditis: outcome predictors in an international cohort study. This retrospective study of fulminant myocarditis across 26 European centers identified lymphocytic myocarditis as the most frequent type and revealed distinct clinical courses based on endomyocardial biopsy findings. Predictors of mortality included the need for mechanical circulatory support, particularly extracorporeal membrane oxygenation, and elevated creatinine levels. These findings underscore the importance of early risk stratification and tailored management strategies in fulminant myocarditis.

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Keywords

chronic limb-threatening ischemia, infrapopliteal disease, amputation, drug-eluting resorbable scaffold, endomyocardial biopsy, mortality, mechanical circulatory support, percutaneous transluminal angioplasty, fulminant myocarditis, lymphocytic myocarditis.

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