In this episode of Exploration Science, Professors Anna Maria Papini and Paolo Rovero talk about their research in peptide science from immunology to developing standards for large-scale production of peptides with Microwave-Assisted SPPS under GMP compliance.

References

An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer. Annunziata D’Ercole, Lorenzo Pacini, Giuseppina Sabatino, Matteo Zini, Francesca Nuti, Arianna Ribecai, Alfredo Paio, Paolo Rovero, and Anna Maria Papini. Organic Process Research & Development 2021 25 (12), 2754-2771. DOI: 10.1021/acs.oprd.1c00368

An Optimized Scalable Fully Automated Solid-Phase Microwave-Assisted cGMP-Ready Process for the Preparation of Eptifibatide. Giuseppina Sabatino, Annunziata D’Ercole, Lorenzo Pacini, Matteo Zini, Arianna Ribecai, Alfredo Paio, Paolo Rovero, and Anna Maria Papini. Organic Process Research & Development 2021 25 (3), 552-563. DOI: 10.1021/acs.oprd.0c00490