Liberal Transfusion in Anemic MI Cases Shows Favorable Results: MINT Study
Description
In patients with myocardial infarction (MI) and anemia, a "liberal" red blood cell (RBC)transfusion strategy significantly reduce the risk of recurrent MI or death within 30 days compared with a "restrictive" transfusion strategy, in the 3500-patient MINT trial.
A liberal transfusion strategy may be the most prudent approach to transfusion in anemic patients with MI
We cannot claim that a liberal transfusion strategy is definitively superior based on our
primary outcome," he said, but "the 95% confidence interval is consistent with treatment effects corresponding to no difference between the two transfusion strategies and to a clinically relevant benefit with the liberal strategy."
The number needed to treat was 40 to see a benefit in the combined outcome of death or recurrent MI at 30 days, The P-value for this was 0.07, "right on the edge" of statistical significance.
"In contrast to other trials in other settings," such as anemia and cardiac surgery, "the
results suggest that a liberal transfusion strategy has the potential for clinical benefit with an acceptable risk of harm."
"While not statistically significant, the results consistently favored a liberal transfusion strategy,"
Notably, cardiovascular death, which was not a specified outcome, was significantly lower in the group who received a liberal transfusion strategy.
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