THE ADAPTABLE STUDY
Description
In this trial, 15,000 patients from 40 centers across the U.S. were self-enrolled and self-randomized between 2016 & 2019.
The Participants were of median age of 67 years
With 35.3% had a history of myocardial infarction (MI) and
53% had coronary revascularization within the previous five years.
The Results showed after median 26 months of follow-up were as follows
No significant difference in the primary effective outcome of all-cause death, MI, or stroke OR
Primary safety outcome of major bleeding requiring blood transfusion at 12 months.
But there was a high rate of dose switching and discontinuation in patients on a higher dose of Aspirin.
Thus this study is very illustrative of fact that low dose Aspirin is equally effective as high dose, and the switch over and discontinuation may be due to GI.
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United States
