Myasthenia Gravis: High-Yield USMLE Topics You Must Know
Update: 2025-04-07
Description
Myasthenia Gravis is the most common neuromuscular junction disorder, and it’s high-yield for Step 1!
Key Features:
- Fluctuating muscle weakness that worsens with activity
- Ptosis, diplopia, dysphagia, and proximal weakness
- Myasthenic crisis → Respiratory failure risk
Diagnosis:
- Ice pack test improves ptosis
- ACh receptor antibodies (highly specific)
- Chest CT to check for thymoma
Treatment:
- Pyridostigmine (AChE inhibitor)
- Thymectomy if thymoma
- Immunotherapy for severe cases
- Myasthenic crisis → IVIG or plasmapheresis
Know how to differentiate it from Lambert-Eaton syndrome (which improves with use)!
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