In this twenty-first episode, Nichola Conlon provides a scientific background, introducing sirtuins and NAD. She then explains why popular NAD+ boosters, NR and NMN, are first-gen products.

Read the transcript

She details how Nuchido formulated the first second-gen product by taking a novel whole systems approach. Lots of NAD, anti-aging, and nutraceutical discussion along the way.

Topics we discussed in this episode

• Recent personal experience with COVID-19


• Her molecular biology PhD focus


• Systems pharmacology


• Help from Aubrey de Gray


• Disillusioned with drug development


• Founding Nuchido


• What are Sirtuins? What is NAD?


• Importance of NAD. Why Boost NAD Levels?


• Inefficiency of First-Gen NAD Supplements: NR and NMN


• Three ingredients to boost NAD


• Pure NAD limitations


• Nicotinamide Riboside (NR)


• Nicotinamide Mononucleotide (NMN)


• 60% increase in NAD “only”


• Second-gen, demonstrated it can be done much better if you take a whole systems approach


• Importance of NAD salvage pathway


• PARP enzymes


• Inability to power sustained high-levels because of salvage pathway deterioration


• First-gen may not be great for epigenetics


• Increases expression of the enzymes in the salvage pathway that are known to decline with age


• Ingredients that reduce the expression of other processes that are actually wasting NAD


• Enzyme called CD38


• Inflammatory levels – CD38 just chews up NAD


• Multiple things that you can do to fix the cell before you even need to put precursors in.


• NAD decreases with age


• Do we Need NAD Supplements?


• Sirtuins and mitochondrial biogenesis


• Boosting your NAD levels, improves mitochondrial function.


• Multiple reasons that are causing the NAD to decline, boosting as with first-gen only the amount of raw material that your cell has is quite naïve


• Second-gen helps fixe your body’s natural ability to make and recycle its own NAD


• Nuchido TIME+ boosts NAD on average by 242%, four times more than the 60% widely cited for first-gen


• ChromaDex vs Elyisum Health


• Terms B3, niacin, nicotinamide, nicotinic acid, NR


• Abram Hoffer and orthomolecular medicine


• Nicotinamide is not likely to be a sirtuin inhibitor,


• How to measure NAD levels


• Nuchido TIME+ ingredients


• Alpha lipoic acid (ALA) and effects on AMPK


• Conversion of NADH to NAD+


• Drift more towards having more NADH in your cell with age


• Pathway called NQO1, converts NADH back to NAD+


• ALA is a really powerful antioxidant, activates NRF2


• ALA vs ALA-R


• Sophora Japonica Extract Rutin, senolytic


• NAMP


• Aging is an inflicted cascade disorder

Show links

• Nuchido (Company Website)


• ChromaDex (Company Website)


• Elysium Health (Company Website)


• Elysium Health, Inc. Loses Appeal of Patent Challenge Decision (Press Release)


• Orthomolecular Medicine (Wikipedia Entry)


• Abram Hoffer (Wikipedia Entry)


• Niacin: The Real Story: Learn about the Wonderful Healing Properties of Niacin (Amazon, Book)


• Orthomolecular Medicine for Everyone (Amazon, Book)


• GlycanAge (Company Website)