You Should Measure the Length of Your Critically-Short Telomeres – EP19: Stephen Matlin (Life Length)
Update: 2020-09-20
Description
In this nineteenth episode, Stephen Matlin introduces telomere biology. He details how testing services typically use Q-PCR which provides an average telomere length and why that doesn’t really mean anything.
Instead the percentage of critically-short, measured using Q-FISH, does. Finally he chats about supplements – telomerase inducers – for growth.
Topics we discussed in this episode
- Introduction to telomere biology
- Hayflick limit, senescent cells, apoptosis
- Telomeres and the hallmarks of aging
- Quantitative PCR derived average telomere length vs shortest telomeres
- Coefficient of variation of lab samples
- Role of supplements in supporting our telomeres and overall biological function
- Declining nutrition in even vegetables
- Telomerase inducers TA-65 and TAM-818
- Telomerase enzyme
- Henrietta Lacks cells, cancer and the Hayflick limit
- Telomerase supplements and cancer
- Telomerase inducer Telomere Benefits™
- Providing biological age scores using telomere measurements
- Telomere length and correlation with healthspan
- Improving upon biomarker Prostate Specific Antigen with Prostate Telomere Associate Variance
Show links
- LifeLength.com (Company Website)
- T.A. Sciences TA-65 (UK/Europe)
- T.A. Sciences TA-65 (Amazon.com)
- Hayflick, His Limit, and Cellular Ageing (Paper)
- The Hayflick Limit (Embryo Project Encyclopedia)
- The End-Replication Problem (Paper)
- Leucocyte Telomere Length And Risk Of Cardiovascular Disease: Systematic Review And Meta-analysis (Paper)
- Association Between Leucocyte Telomere Length And Cardiovascular Disease In A Large General Population In The United States (Paper)
- The Hallmarks of Aging (Paper)
- Coefficient of Variation (Wikipedia Entry)
- A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study (Paper)
- The Telomerase Activator Ta-65 Elongates Short Telomeres And Increases Health Span Of Adult/old Mice Without Increasing Cancer Incidence (Paper)
- Discovery Of Potent Telomerase Activators: Unfolding New Therapeutic And Anti-aging Perspectives (Paper)
- The Nobel Prize in Physiology or Medicine 2009 (Website)
- Defy Time (Website)
- Telomere Benefits™ (Product Link)
- Mathematical Connection Between Short Telomere Induced Senescence Calculation And Mortality Rate Data (Paper)
- Comparison Of Telomere Length Measurement Methods (Paper)
- Beyond Average: Potential For Measurement Of Short Telomeres (Paper)
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