How does RNA biology influence cell function, gene expression, and disease mechanisms? In this episode of Neuroscience Perspectives, host John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester (UR), sits down with Lynne Maquat, PhD, director of the Center for RNA Biology at UR, and J. Lowell Orbison Endowed Chair and Professor of Biochemistry & Biophysics, to explore groundbreaking research in mRNA decay, cellular quality control, and translational research. Dr. Maquat, a world-renowned scientist, shares insights into how fundamental biochemistry, molecular biology, and biophysics drive scientific discovery—from understanding cystic fibrosis, fragile X syndrome, and intellectual disabilities to advancing cancer research, autism studies, and stem cell research. They also discuss the impact of mRNA vaccines, vaccine development, and COVID-19 on modern medicine. Beyond the lab, they dive into the importance of scientific integrity, mentoring scientists, research collaboration, and science education.

🔬 Discover how basic and applied research pave the way for personalized treatments, neurobiology breakthroughs, and scientific innovation. #Neuroscience #RNABiology #ScientificDiscovery

#mRNADecay #GeneExpression #TranslationalResearch #CancerResearch #VaccineDevelopment #AutismResearch #StemCellResearch #ScienceEducation #ScienceCommunication

🧠 Stay Connected

Subscribe: https://www.youtube.com/@URNeuroscience

X: https://x.com/URNeuroscience

BlueSky: https://bsky.app/profile/urneuroscience.bsky.social

LinkedIn: https://www.linkedin.com/company/urneuroscience/

🧠 Experts in this Episode:

Lynne Maquat, PhD: https://www.urmc.rochester.edu/people/112359023-lynne-e-maquat John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe

🧠 Labs Mentioned:

Maquat Lab: https://www.urmc.rochester.edu/labs/maquat

Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG