A recent study in mice explored how a combination of two supplements, lactoferrin and creatine, might help with age-related muscle loss, a condition called sarcopenia. Scientists induced sarcopenia in mice, causing their muscle mass and function to decline. For 8 weeks, these mice were given lactoferrin, creatine, or a mixture of both. The results were promising: the group of mice receiving both lactoferrin and creatine showed the most significant improvements. For example, the lean body content in the sarcopenia model group dropped to around 47-48%, while the group receiving the combination treatment saw their lean body content increase to about 51-52%, bringing them above the levels of the healthy control group (around 50%). In terms of muscle function, the combination group's endurance on a treadmill test was approximately 1200 seconds, a significant improvement compared to the sarcopenia model group (around 600 seconds) and even surpassing the healthy control group (around 900 seconds). Their grip strength also increased to roughly 180g with the combination, compared to about 130g in the model group and 150g in controls. These findings suggest that combining lactoferrin and creatine could be a beneficial nutritional strategy to combat muscle decay associated with aging, potentially by improving how muscles use energy and build protein.

3. Disclaimers:

• "This information is for educational purposes only and should not be interpreted as medical advice."

• "The study discussed was conducted on mice. Further research is needed to confirm these findings in humans."

• "Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications."

• "This Channel does not provide medical advice."

#Sarcopenia #MuscleHealth #Lactoferrin #Creatine #AgingWell

Wu W, Guo X, Qu T, Huang Y, Tao J, He J, Wang X, Luo J, An P, Zhu Y, et al. The Combination of Lactoferrin and Creatine Ameliorates Muscle Decay in a Sarcopenia Murine Model. Nutrients. 2024; 16(12):1958. https://doi.org/10.3390/nu16121958

Sarcopenia, creatine, lactoferrin, muscle mass, muscle function, aging, muscle decay, D-galactose, C57BL/6 mice, muscle strength, endurance, grip strength, lean body mass, nutritional intervention, muscle protein synthesis, energy metabolism, myogenic factors, RNA-seq, mTOR signaling, PI3K-Akt signaling, longevity regulating pathway, muscle atrophy, animal model, skeletal muscle, nutritional supplements