DiscoverProteomics in ProximityProteogenomics of metabolic disease with Mine Koprulu and Dr. Claudia Langenberg
Proteogenomics of metabolic disease with Mine Koprulu and Dr. Claudia Langenberg

Proteogenomics of metabolic disease with Mine Koprulu and Dr. Claudia Langenberg

Update: 2023-10-26
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Welcome to the Olink® Proteomics in Proximity podcast! 
 
 

Below are some useful resources from this episode: 

 

Published study of primary focus

Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C. Proteogenomic links to human metabolic diseases. Nat Metab. 2023 Mar;5(3):516-528. doi: 10.1038/s42255-023-00753-7. Epub 2023 Feb 23. Erratum in: Nat Metab. 2023 Mar 19;: PMID: 36823471; PMCID: PMC7614946. https://pubmed.ncbi.nlm.nih.gov/36823471/

 

Laboratory, first author, and corresponding author of the study

·         Public Health University Research Institute (PHURI), a multidisciplinary research center to drive personalized healthcare: https://www.qmul.ac.uk/phuri/about/

·         Mine Koprulu (first author), PhD student, University of Cambridge: https://www.linkedin.com/in/mine-koprulu-497659b9/  

·         Dr. Claudia Langenberg (corresponding author); Director of PHURI, Queen Mary, University of London; Professor of Computational Medicine, Berlin Institute of Health at Charité: https://www.qmul.ac.uk/phuri/our-people/professor-claudia-langenberg/ 

 

Olink tools and software

·         Olink® Explore 3072, the platform that measured proteins in this study with a next-generation sequencing (NGS) readout: https://olink.com/products-services/explore/

 

UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies 

 

Genotype-Tissue Expression (GTEx) project, a biobank and open-access database to study tissue-specific gene expression and regulation: https://www.gtexportal.org/home/

 

European Prospective Investigation into Cancer (EPIC)-Norfolk study, a prospective cohort of middle-aged individuals from Eastern England: https://www.epic-norfolk.org.uk/ 

 

Genome Aggregation Database (gnomAD), the largest publicly available collection of population variation from harmonized exome and genome sequencing data: https://gnomad.broadinstitute.org/ 

 

 

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Proteogenomics of metabolic disease with Mine Koprulu and Dr. Claudia Langenberg

Proteogenomics of metabolic disease with Mine Koprulu and Dr. Claudia Langenberg

Olink Proteomics