E17   |  19 min   |   Latest   |  Publication Source   

• Podcast based on: Das S, Samaddar S. Recent Advances in the Clinical Translation of Small-Cell Lung Cancer Therapeutics. Cancers. 2025; 17(2):255. https://doi.org/10.3390/cancers17020255
  
  Type: Review  |  Publication date: Jan 14, 2025
  
  
  
  


• Summary: This research review comprehensively examines small-cell lung cancer (SCLC), a highly aggressive and often fatal lung cancer. It details SCLC's cellular origins, neuroendocrine characteristics, and diverse subtypes driven by distinct transcriptional regulators. The review also explores the mechanisms of chemoresistance, focusing on DNA damage response pathways, cancer stem cells, and epigenetic reprogramming. Finally, it summarises recent advancements and ongoing clinical trials investigating novel targeted therapies, including immune checkpoint inhibitors, topoisomerase inhibitors, and agents targeting DLL3, HDACs, and PARP.
  
  
  
  


• Keywords: small-cell lung cancer; molecular subtypes; chemotherapy; resistance

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