Spatial Connectomics: Barcodes, Sequencing, and Analysis
Description
What if we could map every neuron, every connection, and every signal pathway in the brain — not with a microscope, but with DNA barcodes and sequencing?
In this podcast, we explore the groundbreaking field of spatial connectomics, where cutting-edge molecular tools reveal the brain’s wiring diagram at unprecedented resolution.
Each episode uncovers how scientists use DNA barcoding, in situ sequencing, high-throughput imaging, and computational reconstruction to chart the trillions of connections that shape perception, memory, behavior, and disease.
We break down major innovations:
• Barcoded neurons that “tag” their connections
• Molecular tracers that record synaptic events
• Spatial sequencing that reconstructs circuits in 3D
• Machine-learning models that assemble massive neural maps
• Applications in Alzheimer’s, autism, neurodegeneration, and brain-inspired computing
This is the story of how biology, genomics, and advanced computation come together to decode the most complex structure in the known universe — the human brain.
United States
