In this episode, we focus on the history of researchers discovering the clinical applicability of the IL 23/17 axis, with a particular emphasis on psoriasis, psoriatic arthritis and axial SpA

 

·        Intro 0:01

·        In this episode 0:12

·        Leonard Calabrese, DO, is listening! 0:54

·        Recap of last episode 3:09

·        Putting the pieces together 5:12

·        Quick overview of this science heavy episode 6:11

·        What is psoriasis? 7:26

·        Immunosuppressants for psoriasis/ Throwing meds at people and seeing what happens 10:10

·        In the modern world of 1986 – olive oil placebo trial 11:36

·        A quick aside into fungi 12:35

·        What kind of T-cells are involved here? 16:41

·        The TH-1 hypothesis 18:20

·        IL-23 and IL-17 are doing something 19:34

·        Going back to the drawing board in 2004 20:00

·        p40 + p19 = IL-23 21:00

·        IL-23 via minicircle DNA in mice 23:05

·        Brand new and shiny TH-17 25:23

·        The family of IL-17 26:36

·        What do we know about IL-17 and psoriasis? 27:10

·        IL-17A vs IL-17F in mouse studies 27:35

·        Finding the difference between IL-17A and IL-17F in humans 28:23

·        What exactly is IL-17 doing? 29:30

·        The articular manifestations of psoriatic arthritis 30:57

·        Spondylarthritis and the IL 23/17 axis 33:56

·        T-cells we haven’t talked about 35:40

·        Summary of this episode 39:08

·        Thanks for listening 41:34

 

We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

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Bjerke R J. Acta Derm Venereol. 1982;PMID:6179355

Cargill M, et al. Am J Hum Genet. 2007;doi:10.1086/511051

Chan J R, et al. J Exp Med. 2006;doi:10.1084/jem.20060244

Cuthbert R J, et al. Ann Rheum Dis. 2019;doi:10.1136/annrheumdis-2019-215210

Ellis C N, et al. JAMA. 1986;doi:10.1001/jama.1986​

Ettehadi P, et al. Clin Exp Immunol. 1994;doi:10.1111/j.1365-2249.1994.tb06244.x

Furue M, et al. Int J Mol Sci. 2020;doi:10.3390/ijms21041275

Gooderham M J, et al. J Eur Acad Dermatol Venereol. 2018;doi:10.1111/jdv.14868

Lee E, et al. J Exp Med. 2004;doi:10.1084/jem.20030451

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