The Unnecessarily Complex Story of Rheumatoid Factor
Description
The story of rheumatoid factor could be a 10 minute episode, but in this episode, we dig deep into the history of the lab techniques leading up to this discovery…that happened twice.
· Intro 0:04
· Rheumatoid factor quick background and history 00:22
· Rheumatology blood tests 2:47
· What is Rheumatoid factor? 3:39
· Spiderman and latex agglutination: Testing for rheumatoid factor 4:49
· 4:54
· The double discovery of rheumatoid factor 7:52
· Putting agglutination on the medical map in 1896 10:03
· Pop Quiz! 11:04
· Serotherapy 13:00
· When did we start using agglutination for testing? 14:07
· First discovery of blood groups 14:44
· The complement fixation test 17:12
· Testing for syphilis with complement fixation and agglutination 20:53
· The first discovery of rheumatoid factor 24:02
· We forget about rheumatoid factor 27:48
· Rediscovering rheumatoid factor 28:20
· Analytical ultracentrifugation 32:55
· What rheumatoid factor is used for 35:50
· Thanks for listening 38:09
We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.
References:
Assadian O et al. Wien Klin Wochenschr. 2010;doi:10.1007/s00508-009-1297-1
Edelman GM, et al. J Exp Med. 1958;doi:10.1084/jem.108.1.105
Franklin EC, et al. J Exp Med. 1957;doi:10.1084/jem.105.5.425
Fraser KJ. Semin Arthritis Rheum. 1988;doi:10.1016/0049-0172(88)90035-2
Jonsson R. Ann Rheum Dis. 2020;doi:10.1136/annrheumdis-2019-216822
Mohd Noor NH, et al. Cureus. 2024;doi:10.7759/cureus.68903
Tan EM, et al. J Exp Med. 2016;doi:10.1084/jem.20160792
Disclosures: Brown reports no relevant financial disclosures.
United States
