This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright take on one of the biggest misinformation waves in popular health media: the rise of “microdosed” GLP‑1s and so‑called “GLP‑1 diets.” 

As GLP‑1 medications dominate headlines and social media feeds, the hosts cut through the noise to explain what’s actually safe, what’s marketing hype, and why restrictive diets go against metabolic science. 

Dr. Cooper reveals how calorie‑cutting research became misinterpreted, how compounded microdoses are being promoted like supplements, and why “just eat less” remains one of the most harmful messages for people trying to improve their metabolic health. 

From the hormonal backlash of dieting to potentially-dangerous online telehealth shortcuts, this episode exposes how the new era of “skinny shots” and influencer‑driven microdosing campaigns echo decades of failed diet culture.

Key Takeaways:

• GLP‑1 medications were never meant to be microdosed — these are serious prescription treatments, not vitamin‑like supplements.
• “GLP‑1 diets” persist because clinical trials paired the drugs with low‑calorie plans — but science hasn’t yet proven those restrictions help long‑term.
• Chronic calorie restriction weakens metabolism, disrupts hormones, and sets up “defensive weight gain.”
• Compounded or telehealth‑prescribed GLP‑1 versions are often untested and can be risky; many forms haven’t even been through FDA approval.
• Real progress comes from fueling your metabolism — eating enough, exercising with support, and stabilizing your brain’s hunger signals.

Personal Stories & Practical Advice:Andrea opens up about the challenge of “mechanical eating” on GLP‑1 therapy — remembering to eat even when not hungry — while Mark shares how his own food relationship transformed once he focused on fueling, not restriction. Dr. Cooper emphasizes her 25‑year‑old shift away from calorie‑cutting, showing how patients thrive when metabolism is strengthened, not starved.

Resources from the episode:Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go (and stay) away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

Check out our new website where you can ask a mailbag question.Have a question for Dr. Cooper, a show idea, feedback, or just want to connect? Email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.

Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.