DiscoverDry Fasting ClubThe Science Behind How Dry Fasting Reboots Autophagy and Fixes Cellular Health
The Science Behind How Dry Fasting Reboots Autophagy and Fixes Cellular Health

The Science Behind How Dry Fasting Reboots Autophagy and Fixes Cellular Health

Update: 2024-03-06
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Dry fasting has been hailed for its potential benefits in healing, longevity, and weight loss, primarily due to its unique mechanism of promoting autophagy independent of nutrient starvation, specifically through dehydration. This process is crucial for those dealing with severe illnesses, particularly autoimmune diseases, which may impair autophagic functions due to various factors like mitochondrial dysfunction and disruption of macroautophagy through the ULK1 System. Testing autophagic pathways through methods such as the ULK1 Kinase Assay can provide insight into the state of one's macroautophagy pathways, offering a deeper understanding rather than a direct solution. Dry fasting serves as a loophole to potentially rectify autophagic dysfunctions by circumventing the nutrient-dependent ULK1 pathway, leveraging hypertonic stress induced by dehydration. This stress, both hypovolemic and hypertonic, has been shown to be manageable in experienced individuals over a 5-day dry fast, suggesting its safety and effectiveness in initiating profound cellular healing and autophagy, notably through microtubule reorganization. Microtubules, essential for cellular health and autophagy, facilitate the transport of autophagosomes to lysosomes for degradation. A study examining hypertonic stress highlights its role in enhancing autophagy and microtubule-dependent autophagosomal clusters, indicating that dry fasting not only boosts autophagy but also restructures cellular components for improved function. This method of fasting, particularly when transitioning from a dry to a water fast after reaching an acidotic crisis, may offer a balanced approach to harnessing autophagy's full potential while mitigating risks, marking a significant stride in understanding cellular protection and healing in hypertonic conditions.

#waterfast #dryfast #autophagy #fasting #stress #hormesis #dehydration #science

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The Science Behind How Dry Fasting Reboots Autophagy and Fixes Cellular Health

The Science Behind How Dry Fasting Reboots Autophagy and Fixes Cellular Health

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