Urticarial Vasculitis, Part 2: Walking the Balance Beam of Allergy and Rheumatology
Description
This episode digs into the pathophysiology of urticaria vasculitis from anti-C1q to the story of bradykinin.
· Intro 0:11
· In this episode 0:22
· Review of episode 83 1:23
· Listen to previous episode, The Complement System for Dunces 4:09
· Anti-C1q antibodies 6:26
· Lupus, anti-C1q and lupus nephritis 9:33
· What happens when you inject anti-C1q in a mouse? 12:56
· The allergy component: anti-C1q, urticaria and angioedema 17:36
· Bradykinin-mediated angioedema and C1q deficiency 24:20
· What is the kinin kallikrein system? 26:21
· French researchers in 1909: human urine injected in dogs 27:30
· How is this relevant to urticarial vasculitis? 31:08
· SERPING1 gene mutation 31:23
· Summary 32:06
· COPD association with urticarial vasculitis 33:51
· Coming up in episode 85 35:28
· Thanks for listening 35:45
Disclosures: Brown reports no relevant financial disclosures.
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References:
Busse P, et al. J Allergy Clin Immunol Pract. 2022;doi:10.1016/j.jaip.2021.11.011.
Davis MDP, et al. J Allergy Clin Immunol Pract. 2018;doi:10.1016/j.jaip.2018.05.006.
Dorn JM, et al. Ann Allergy Asthma Immunol. 2023;doi:10.1016/j.anai.2023.06.014.
Marzano AV, et al. J Allergy Clin Immunol. 2022;doi:10.1016/j.jaci.2022.02.007.
Siegert CE, et al. Clin Immunol Immunopathol. 1993;doi:10.1006/clin.1993.1066.
United States
