DiscoverWinning Cures EverythingWeek 11 College Football Picks for the 10 Biggest Games! 2025
Week 11 College Football Picks for the 10 Biggest Games! 2025

Week 11 College Football Picks for the 10 Biggest Games! 2025

Update: 2025-11-04
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Week 11’s 10 Biggest Games are loaded with edges—and we’ve got picks backed by pace, success rate, PPA margin, and finishing-drives data you can actually use before kickoff. We start at Kinnick with Oregon vs Iowa (elite trench chess match), roll into LSU at Alabama (Tide passing efficiency vs LSU’s road form), and hit BYU at Texas Tech with College GameDay in Lubbock (BYU’s TO/ST edge vs Tech’s grind).

We keep it moving: Indiana at Penn State (Hoosiers’ 2H dominance), Texas A&M at Missouri (freshman QB vs Elko defense), Navy at Notre Dame (Irish roll, number too big), Auburn at Vanderbilt (interim spark + defense travel), and the sandwich spot Georgia at Mississippi State (Starkville cover machine). We close with leverage games: Southern Miss at Arkansas State (Jonesboro ATS wagon) and a late-night San Diego State at Hawaii showdown (Aztecs’ pass D vs Run-N-Shoot).

Topics covered: ATS picks, MAC/Sun Belt/MWC angles, rushing success rate, passing success rate, PPA margin, red-zone TD rate, turnover margin, strength of schedule, and where the market disagrees with the models.

  • 0:58 Oregon vs Iowa
  • 6:34 LSU vs Alabama
  • 12:15 BYU vs Texas Tech
  • 18:37 Indiana vs Penn State
  • 24:18 Texas A&M vs Missouri
  • 29:42 Navy vs Notre Dame
  • 35:04 Auburn vs Vanderbilt
  • 42:13 Georgia vs Mississippi State
  • 48:29 Southern Miss vs Arkansas State
  • 53:31 San Diego State vs Hawaii


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Week 11 College Football Picks for the 10 Biggest Games! 2025

Week 11 College Football Picks for the 10 Biggest Games! 2025

Gary Segars, College Football, Football