Why Weight Loss Gets Harder in Your 40s — The Hormone–Metabolism Link
Update: 2025-11-04
Description
In this episode, Dr. Alessia Roehnelt — double board-certified endocrinologist and founder of EndoHealth MD — unpacks the real reasons metabolism feels different in your 40s and 50s.
She explains how shifting levels of estrogen, progesterone, thyroid, and cortisol affect muscle mass, insulin sensitivity, and fat storage — and what you can do to restore metabolic balance.
You’ll learn:
- Why estrogen loss changes where your body stores fat
- How muscle is your most important metabolic organ
- What blood-sugar swings do to energy, cravings, and mood
- How stress, sleep, and thyroid tie it all together
- Practical steps to rebuild your metabolic resilience
💡 Resources Mentioned:
- Dr. Alessia Roehnelt – EndoHealth MD
- Follow @endohealthdoc on Instagram https://www.instagram.com/endohealthdoc
- Harvard Health – The Role of Estrogen in Weight Regulation https://www.health.harvard.edu/womens-health/why-women-gain-weight-at-midlife
- NIH – Insulin Resistance and Midlife Metabolism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678504/
- Sleep Foundation – Hormones and Sleep Quality https://www.sleepfoundation.org/women-sleep/hormones-and-sleep
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