“Guess I Was Wrong About AIxBio Risks” by J Bostock
Description
I was slightly worried about sociohazards of posting this here, but the cat's already out of the bag on this one: the authors of the paper put it up on BioRXiv and got an article written about them in Nature, as well as getting into a bunch of newspapers and all over twitter. I expect that the marginal audience of LessWrong is much more heavily enriched in people who'll use this information to do good than to do evil.
TL;DR:
If anyone reading this works in Biosecurity: nucleotide synthesis companies should start using protein structure annotation as part of their screening protocol for genes, if they aren't already.
Intro
The Fermi Paradox is the question of why we don't see any evidence of aliens spreading out across the galaxy, despite there being loads of planets on which intelligent life could evolve.
The Germy Paradox is the question of [...]
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Outline:
(00:48 ) Intro
(01:23 ) I
(04:34 ) II
(06:52 ) III
The original text contained 4 footnotes which were omitted from this narration.
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First published:
September 29th, 2025
Source:
https://www.lesswrong.com/posts/k5JEA4yFyDzgffqaL/guess-i-was-wrong-about-aixbio-risks
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Narrated by TYPE III AUDIO.
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Images from the article:


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