#825: Dr. Dominic D’Agostino — All Things Ketones, How to Protect the Brain and Boost Cognition, Sardine Fasting, Diet Rules, Revisiting Metformin and Melatonin, and More
Description
Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.
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Timestamps:
[00:00:00 ] Start.
[00:14:43 ] Why I'm interested in ketogenic strategies for neurodegenerative prevention.
[00:16:18 ] Mary and Steve Newport's ketone-linked temporary cognitive improvements.
[00:18:18 ] A mechanisms overview for Alzheimer's/dementia.
[00:21:25 ] The immune system as longevity's "fifth horseman" — and why metabolic control is key.
[00:22:04 ] How to measure ketones and GKI.
[00:23:00 ] Fasting vs. ketogenic diet.
[00:24:18 ] There's nothing fishy about sardine fasting.
[00:28:32 ] My hiatal hernia discovery and increased cancer risk concerns.
[00:30:04 ] HSCRP as a superior biomarker to LDL for cardiovascular risk.
[00:31:57 ] Glucose tolerance testing revelations and CGM importance.
[00:31:57 ] Upgrading the metabolic machinery through keto without getting bored.
[00:42:07 ] What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption.
[00:43:42 ] Dom's day-to-day diet regimen.
[00:45:56 ] How Dom optimizes his aging dogs with ketones, SARMs, and supplements.
[00:51:30 ] Supplementing for sleep disruption while fasting.
[00:55:41 ] Why Dom doesn't have misgivings about melatonin.
[00:59:15 ] Shingles prevention through fasting protocols.
[01:00:15 ] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.
[01:03:54 ] Dom at 50-something: Current meal timing and composition.
[01:05:57 ] Blue zone observations: Greek and Sardinian longevity habits.
[01:08:16 ] Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio.
[01:15:18 ] Ketone metabolic therapy for cancer.
[01:18:15 ] The metabolic psychiatry revolution.
[01:22:10 ] The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers.
[01:28:27 ] Metformin vs. berberine.
[01:31:43 ] The low-dose neuroprotective potential of GLP-1 drugs.
[01:34:58 ] NAD research: MIB-626 and stabilized forms for mitochondrial health.
[01:39:48 ] Idebenone, CoQ10, and the Deanna protocol for ALS.
[01:42:05 ] Dom's supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin.
[01:44:43 ] KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts.
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Show notes for this episode: https://tim.blog/2025/09/03/dr-dominic-dagostino-all-things-ketones/
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