DiscoverThe Visser PodcastAge Reversal 2: NMN & NR, Metformin and Rapamycin -The Hype, The Choke and The Protector
Age Reversal 2: NMN & NR, Metformin and Rapamycin -The Hype, The Choke and The Protector

Age Reversal 2: NMN & NR, Metformin and Rapamycin -The Hype, The Choke and The Protector

Update: 2024-01-31
Share

Description

Another juicy installment in our age reversal series. Today we are talking about the science behind some of the most popular age reversal trends and trials. Here are some quick links to the studies mentioned in the video & for more information

The first human clinical study for NMN has started in Japan Kazuo Tsubota: https://www.nature.com/articles/npjamd201621

Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms Sheng Chen:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965502/

Effects of putative metformin targets on phenotypic age and leukocyte telomere length: a mendelian randomisation study using data from the UK Biobank Shan Luo, PhD :
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00085-5/fulltext

Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update, Author links open overlay panelZelton Dave Sharp:
https://www.sciencedirect.com/science/article/pii/S0531556523000876

<img src="data:image/jpeg;base64,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

Comments 
00:00
00:00
1.0x

0.5x

0.8x

1.0x

1.25x

1.5x

2.0x

3.0x

Sleep Timer

Off

End of Episode

5 Minutes

10 Minutes

15 Minutes

30 Minutes

45 Minutes

60 Minutes

120 Minutes

Age Reversal 2: NMN & NR, Metformin and Rapamycin -The Hype, The Choke and The Protector

Age Reversal 2: NMN & NR, Metformin and Rapamycin -The Hype, The Choke and The Protector

Dr. Richard Visser