Autism & Auditory: Low Inhibition + High Excitation = Sensory Overload
Description
Starting with von Békésy’s traveling wave and the cochlea’s +80 mV biological battery, we move millisecond-by-millisecond through the auditory brainstem response (ABR Waves I–V), auditory nerve, cochlear nucleus, superior olivary complex, inferior colliculus, thalamic reticular nucleus, and finally primary auditory cortex (A1). The Endocochlear Potential (EP) is the highest DC voltage in the human body. As signals travel, excitation-inhibition attempts to balance that. When intact, brains can filter noise and locate meaningful sound. In Autism, reduced GABAergic sculpting (parvalbumin, somatostatin, and VIP interneuron dysfunction) plus lower myelination and a delayed Wave V — already detectable on the newborn hearing screen — turn ordinary environments into an unfiltered flood. The result is listening dissonance: a moment-to-moment perceptual struggle that collapses 40-Hz gamma, recruits massive frontal effort and emotional regions of the brain, frequently ends in sensory overload, shutdown, or literal pain. We close with the exact equation the pathway reveals: Low Inhibition + High Excitation = Sensory Overload.
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0:00 Chroma Light Devices and Daylight Computer Company
01:56 Audition & Autism; von Békésy Traveling Wave & Tonotopy; Hair Cells & Cochlear Amplifier
04:20 Endocochlear Potential (+80 mV Battery); Bioelectric Currents
06:30 Stria Vascularis, Melanin, & Water Role
08:15 Auditory Nerve – ABR Wave I (1.6 ms)
08:36 ABR Wave II (2.7 ms)09:00 Cochlear Nucleus & Early E:I
12:10 ABR Wave III – Superior Olivary Complex (3.8 ms)
12:13 Binaural Processing & Calyx of Held
15:00 ABR Wave V – Inferior Colliculus (5.6 ms)
15:42 Inferior Colliculus Gamma & Cell Types
18:00 Thalamus MGN & TRN Noise-Canceling
21:30 2021 Newborn ABR Study – Prolonged Wave V Biomarker
24:30 Listening Dissonance Explained
28:30 Auditory Cortex Gamma Collapse in Autism
32:30 Primary Auditory Cortex A1 Mini-Columns
36:00 Parvalbumin, Somatostatin & VIP Interneurons
39:00 Formula: Low GABA + High Excitation = Overload & Pain
YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA
email: info.fromthespectrum@gmail.com







