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Summary Chapter 3.12 Aminoglycosides

Chapter 3.12 covers aminoglycosides, a potent broad-spectrum antibiotic class that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Commonly used for severe infections like streptococcal endocarditis, they are administered intravenously or intramuscularly. Major concerns include nephrotoxicity, ototoxicity, and neurotoxicity, requiring close monitoring of renal function, hearing, and nerve damage.

Multiple Choice Questions

1. How do aminoglycosides work?
   a) Disrupting cell walls
   b) Inhibiting protein synthesis
   c) Blocking RNA transcription
   d) Preventing DNA replication
2. Which condition can be treated with aminoglycosides?
   a) Hypertension
   b) Streptococcal endocarditis
   c) Diabetes
   d) Migraine
3. Which side effect should be closely monitored?
   a) Hypertension
   b) Ototoxicity
   c) Hair loss
   d) Weight gain
4. How are aminoglycosides usually administered?
   a) Orally
   b) Topically
   c) Intravenously or intramuscularly
   d) Subcutaneously
5. Patients should be advised to:
   a) Avoid sunlight
   b) Monitor for tinnitus
   c) Take with antacids
   d) Increase salt intake

Answer Key

1. b) Inhibiting protein synthesis
2. b) Streptococcal endocarditis
3. b) Ototoxicity
4. c) Intravenously or intramuscularly
5. b) Monitor for tinnitus