In this expert-led video, Dr. Nadege Gunn, a gastroenterologist and hepatologist based in Waco, Texas, offers a practical and up-to-date overview of primary biliary cholangitis (PBC)—a chronic autoimmune liver disease that primarily affects women and can progress to cirrhosis if not treated early. Dr. Gunn breaks down the key steps in diagnosing PBC using simple blood tests, including alkaline phosphatase and antimitochondrial antibody levels, and highlights the importance of non-invasive fibrosis assessment tools like elastography. She discusses first-line treatment with ursodeoxycholic acid (UDCA) and reviews second-line therapies such as obeticholic acid and newer agents with PPAR mechanisms that are emerging in 2024 to address both biochemical response and symptom control, including pruritus. With a focus on early diagnosis, personalized care, and integrating evolving therapies, Dr. Gunn emphasizes the need to proactively manage PBC to prevent progression and improve long-term outcomes. This video is a must-watch for healthcare professionals seeking a concise yet comprehensive clinical approach to PBC.