In this video, Dr. Sonal Kumar, hepatologist at Weill Cornell Medical College in New York City, discusses the complex and often debilitating symptoms associated with Primary Biliary Cholangitis (PBC)—a chronic autoimmune liver disease. Dr. Kumar provides expert insight into symptom identification and management strategies for pruritus (itching), fatigue, jaundice, dry eyes and mouth (Sjögren's overlap), and brain fog. She emphasizes that symptom burden in PBC does not always align with disease severity, meaning even patients with early-stage or well-controlled liver disease may experience significant quality-of-life disruptions. The video explores first-line and second-line treatments for pruritus, techniques to manage fatigue, and supportive therapies for brain fog and dryness. Dr. Kumar also highlights the importance of multidisciplinary care and addressing coexisting mental health concerns to optimize outcomes. For healthcare providers managing patients with PBC, this presentation reinforces the need for a personalized, symptom-focused approach to care.