DiscoverMeta Health: Mindfulness Meets MetabolismS1E29: Acetyl CoA, Citrate, and the Metabolic Merry-Go-Round
S1E29: Acetyl CoA, Citrate, and the Metabolic Merry-Go-Round

S1E29: Acetyl CoA, Citrate, and the Metabolic Merry-Go-Round

Update: 2023-07-06
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Description

I've selected 2 key metabolic ingredients, Acetyl CoA and Citrate, to explain nutrition metabolism in further detail. I've also selected a different storyline, the mitochondrial amusement park and the Kreb's merry-go-round, to help you visualize some of the most fundamental steps of metabolism. In this episode we cover:

  • Acetyl CoA's role as a key metabolic conductor
  • The metabolic merry-go-round used to explain Kreb's cycle
  • The importance of the Citrate sensor in switching between anabolism and catabolism
  • How these concepts are tied to the root cause for weight gain and insulin resistance
  • A critique of B-vitamin supplements as "energy producers"
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S1E29: Acetyl CoA, Citrate, and the Metabolic Merry-Go-Round

S1E29: Acetyl CoA, Citrate, and the Metabolic Merry-Go-Round

Ronesh Sinha, MD