Scientist Explains The Powerful Role Of Nitric Oxide In Preventing Alzheimer’s Disease And How To Protect Our Brains With Nathan Bryan, PhD
3Digest
This episode continues the discussion on nitric oxide and its crucial role in preventing and reversing chronic diseases. Dr. Nathan Bryan, a leading expert in nitric oxide research, delves into the detrimental effects of proton pump inhibitors (PPIs) on nitric oxide production, explaining how they disrupt the body's natural production of this vital molecule. He emphasizes the importance of restoring nitric oxide levels through dietary changes, regular exercise, and avoiding harmful habits. The episode then explores various ways to assess nitric oxide levels, including symptom analysis, saliva test strips, and the Endopat test, which measures endothelial function. Dr. Bryan highlights the importance of a holistic approach to health, emphasizing the need to address root causes of nitric oxide deficiency through lifestyle modifications, dietary changes, and stress management. He also discusses the potential for pharmaceutical interventions in the future, emphasizing the importance of restorative physiology over traditional pharmacology. The episode concludes with Dr. Bryan's recommendations for boosting nitric oxide levels, including a nutrient-dense diet, regular exercise, and the use of nitric oxide supplements.
Outlines
Nitric Oxide: The Holy Grail for Chronic Disease
This Chapter introduces the concept of nitric oxide as the "holy grail" for preventing and reversing chronic diseases. Dr. Bryan explains how nitric oxide plays a vital role in maintaining healthy blood vessels and preventing the onset of cardiovascular disease, the leading cause of death worldwide. He highlights the four hallmarks of disease: low blood flow, inflammation, oxidative stress, and immune dysfunction, and how nitric oxide effectively addresses each of these issues.
The Connection Between PPIs and Alzheimer's Disease
This Chapter explores the link between proton pump inhibitors (PPIs), commonly prescribed for acid reflux, and Alzheimer's disease. Dr. Bryan reveals that long-term use of PPIs has been associated with a significant increase in the risk of developing Alzheimer's. He explains that PPIs suppress stomach acid production, which is essential for nitric oxide production and the absorption of vital nutrients. This disruption in nitric oxide levels can contribute to the development of Alzheimer's disease.
Lifestyle Factors Contributing to Low Nitric Oxide
This Chapter delves into the lifestyle factors that contribute to low nitric oxide levels, which can increase the risk of chronic diseases. Dr. Bryan identifies excessive sugar consumption, a sedentary lifestyle, and the use of mouthwash and fluoride toothpaste as major culprits. He explains how these factors disrupt the body's natural nitric oxide production, leading to a cascade of health problems.
Understanding Nitric Oxide and Its Role in the Body
This Chapter provides a comprehensive overview of nitric oxide, its role in the body, and its significance in maintaining health. Dr. Bryan explains that nitric oxide is a gas molecule that acts as a signaling molecule, facilitating communication between cells. He highlights its involvement in various biological functions, including blood vessel dilation, long-term memory potentiation, immune response, and pain perception.
Dietary and Lifestyle Strategies to Boost Nitric Oxide
This Chapter focuses on dietary and lifestyle strategies to boost nitric oxide production and improve overall health. Dr. Bryan emphasizes the importance of a balanced diet, regular exercise, and avoiding harmful habits like excessive sugar consumption, a sedentary lifestyle, and the use of mouthwash and fluoride toothpaste. He also discusses the role of sunlight exposure in nitric oxide production.
Nitric Oxide and High Blood Pressure
This Chapter explores the connection between nitric oxide and high blood pressure. Dr. Bryan explains that nitric oxide's vasodilating properties help regulate blood pressure by widening blood vessels and reducing pressure. He highlights the role of oral bacteria in nitric oxide production and its impact on blood pressure regulation. He also discusses the limitations of traditional blood pressure medications and the potential benefits of addressing oral dysbiosis.
The Importance of Oral Health for Overall Health
This Chapter emphasizes the importance of oral health for overall health and its connection to nitric oxide production. Dr. Bryan discusses the detrimental effects of root canals and the potential link between oral infections and chronic diseases, including cancer. He highlights the need for a holistic approach to dental care, considering the impact of oral dysbiosis on systemic health.
The Impact of PPIs on Nitric Oxide Production
This Chapter delves deeper into the mechanism by which proton pump inhibitors (PPIs) disrupt nitric oxide production. Dr. Bryan explains that PPIs not only inhibit stomach acid production, which is essential for nitric oxide production, but also interfere with the absorption of vital nutrients and inhibit an enzyme that regulates nitric oxide levels. He emphasizes the importance of understanding the long-term consequences of PPI use and exploring alternative approaches to managing acid reflux.
Assessing Nitric Oxide Levels
This Chapter explores various methods for assessing nitric oxide levels, including symptom analysis, saliva test strips, and the Endopat test, which measures endothelial function. Dr. Bryan discusses the limitations of saliva test strips and emphasizes the importance of the Endopat test as a reliable indicator of endothelial health. He also highlights the importance of a holistic approach to health, considering various factors that can influence nitric oxide production.
Boosting Nitric Oxide Levels
This Chapter focuses on Dr. Bryan's recommendations for boosting nitric oxide levels, including a nutrient-dense diet, regular exercise, and the use of nitric oxide supplements. He emphasizes the importance of a holistic approach to health, addressing root causes of nitric oxide deficiency through lifestyle modifications, dietary changes, and stress management. He also discusses the potential for pharmaceutical interventions in the future, emphasizing the importance of restorative physiology over traditional pharmacology.
Dr. Bryan's Work and Resources
This Chapter provides information on how to follow Dr. Bryan's work and stay updated on his projects. He encourages listeners to follow his YouTube channel, visit his educational website, and explore his company's website for information on nitric oxide products and drug development. He also emphasizes the importance of seeking out reliable information and avoiding misleading claims about nitric oxide supplements.
Keywords
Nitric Oxide
Nitric oxide (NO) is a gas molecule that acts as a signaling molecule in the body. It plays a crucial role in various biological functions, including blood vessel dilation, immune response, and nerve signaling. Nitric oxide is produced by the lining of blood vessels, neurons, and immune cells. It is essential for maintaining healthy blood flow, reducing inflammation, and protecting against oxidative stress and immune dysfunction. A decline in nitric oxide production is a key factor in the development of chronic diseases.
Proton Pump Inhibitors (PPIs)
Proton pump inhibitors (PPIs) are a class of drugs commonly prescribed for acid reflux and other gastrointestinal disorders. They work by suppressing the production of stomach acid. While PPIs can provide short-term relief from acid reflux symptoms, long-term use has been linked to an increased risk of heart attacks, strokes, Alzheimer's disease, and other health problems. PPIs disrupt nitric oxide production, which is essential for maintaining healthy blood vessels and protecting against chronic diseases.
Endothelial Function
Endothelial function refers to the health and proper functioning of the inner lining of blood vessels, known as the endothelium. It plays a crucial role in regulating blood flow, preventing blood clots, and protecting against cardiovascular disease. Nitric oxide is a key molecule involved in endothelial function, promoting vasodilation and reducing inflammation. Impaired endothelial function is a significant risk factor for heart disease and other chronic conditions.
Reactive Hyperemia
Reactive hyperemia is a physiological response to a temporary blockage of blood flow to a tissue. When the blockage is removed, blood flow to the tissue increases significantly, resulting in a flush or redness. This response is a direct measure of the body's ability to produce nitric oxide, which is essential for vasodilation and restoring blood flow. A reduced reactive hyperemia response can indicate impaired endothelial function and an increased risk of cardiovascular disease.
Restorative Physiology
Restorative physiology is a medical approach that focuses on restoring the body's natural functions and promoting optimal health. It emphasizes the use of natural therapies, lifestyle modifications, and targeted interventions to address the root causes of disease. In contrast to traditional pharmacology, which often involves inhibiting biochemical reactions, restorative physiology aims to support and enhance the body's natural processes.
Micronutrient Analysis
Micronutrient analysis is a laboratory test that measures the levels of essential vitamins, minerals, and other micronutrients in the blood. It can help identify deficiencies or imbalances in nutrient intake, providing valuable information for personalized dietary and supplement recommendations. Micronutrient analysis can be particularly helpful for individuals seeking to optimize their health and prevent chronic diseases.
Endopat Test
The Endopat test is a non-invasive medical test that measures endothelial function, which is the health and proper functioning of the inner lining of blood vessels. It uses a device called pulse arterial tonometry (PAT) to assess reactive hyperemia, a physiological response to a temporary blockage of blood flow. The Endopat test provides valuable insights into cardiovascular health and can help identify individuals at risk for heart disease.
Soft Plaque
Soft plaque is a type of plaque buildup in arteries that is less stable and more prone to rupture than calcified plaque. It is composed of cholesterol, fat, and inflammatory cells. Soft plaque can lead to sudden cardiac events, even in individuals with relatively low levels of stenosis (narrowing of the arteries). Nitric oxide plays a crucial role in stabilizing soft plaque and reducing the risk of rupture.
Stress Management
Stress management refers to the techniques and strategies used to cope with stress and reduce its negative effects on physical and mental health. Effective stress management techniques include exercise, relaxation techniques, mindfulness, and seeking social support. Chronic stress can contribute to a decline in nitric oxide production, increasing the risk of chronic diseases. Therefore, managing stress is essential for maintaining optimal health.
Q&A
Why is nitric oxide considered the "holy grail" for chronic disease?
Nitric oxide is essential for maintaining healthy blood vessels, reducing inflammation, and combating oxidative stress and immune dysfunction. A decline in nitric oxide production is a key factor in the development of chronic diseases, making it a crucial target for prevention and treatment.
What are the detrimental effects of proton pump inhibitors (PPIs) on nitric oxide production?
PPIs suppress stomach acid production, which is essential for nitric oxide production and the absorption of vital nutrients. They also inhibit an enzyme that regulates nitric oxide levels. This disruption in nitric oxide levels can contribute to the development of chronic diseases, including heart attacks, strokes, and Alzheimer's disease.
What are some lifestyle factors that contribute to low nitric oxide levels?
Excessive sugar consumption, a sedentary lifestyle, and the use of mouthwash and fluoride toothpaste are major contributors to low nitric oxide levels. These factors disrupt the body's natural nitric oxide production, leading to a cascade of health problems.
How can I boost my nitric oxide levels?
You can boost your nitric oxide levels by adopting a healthy lifestyle that includes a balanced diet, regular exercise, and avoiding harmful habits like excessive sugar consumption, a sedentary lifestyle, and the use of mouthwash and fluoride toothpaste. Sunlight exposure can also help increase nitric oxide production.
What is the connection between nitric oxide and high blood pressure?
Nitric oxide's vasodilating properties help regulate blood pressure by widening blood vessels and reducing pressure. A decline in nitric oxide production can lead to vasoconstriction, increasing blood pressure and contributing to cardiovascular disease.
Why is oral health important for overall health?
The oral microbiome plays a crucial role in maintaining oral health and can influence overall health. Certain bacteria in the oral microbiome produce nitric oxide, which is essential for regulating blood pressure and protecting against chronic diseases. Oral infections, such as those associated with root canals, can release toxins into the bloodstream, contributing to chronic inflammation and other health problems.
What are some alternative approaches to managing acid reflux?
Instead of relying on PPIs, consider exploring alternative approaches to managing acid reflux, such as dietary changes, lifestyle modifications, and natural supplements. Consult with a healthcare professional to determine the best course of action for your individual needs.
What are some tips for improving oral health and boosting nitric oxide production?
Ditch fluoride toothpaste and traditional mouthwash. Use a natural toothpaste that remineralizes teeth and supports a healthy microbiome. Consider using a natural mouth rinse or a tongue scraper. Drink filtered water to avoid exposure to harmful chemicals. Consult with a biological or functional dentist to address any underlying oral health issues.
What is the importance of a holistic approach to dental care?
A holistic approach to dental care considers the impact of oral health on overall health. It involves addressing underlying oral health issues, such as infections and dysbiosis, and promoting a healthy oral microbiome. This approach can help prevent chronic diseases and improve overall well-being.
What are some resources for learning more about nitric oxide and its role in health?
Dr. Nathan Bryan's website and social media channels provide valuable information about nitric oxide research and its implications for health. You can also find articles and resources on the topic from reputable health organizations and websites.
Show Notes
This episode is brought to you by Cozy Earth, Fatty15, and Birch Living.
Cardiovascular disease still ranks as the leading cause of death for both men and women. Surprisingly, half of those affected show no symptoms before an event. Low levels of nitric oxide—a molecule that promotes vasodilation and smooth blood flow—could be primarily responsible. By recognizing the signs of deficiency, we can raise our levels and lower our risk.
Today on The Dhru Purohit Show, Dhru sits down for round two with Dr. Nathan Bryan to discuss why nitric oxide is the holy grail of molecules for long-term health. Dr. Bryan shares the four hallmarks of disease, the consequences of antacid overuse, and the correlation between lower nitric oxide and the risk of Alzheimer’s disease. Dr. Bryan also explains which lifestyle factors can hinder and boost nitric oxide production, how to test your levels, and symptoms that signal a deficiency.
Dr. Nathan Bryan is a renowned biomedical researcher known for his groundbreaking work on nitric oxide (NO) biology. Dr. Bryan's research has significantly advanced our understanding of NO's critical roles in cardiovascular health, immune function, and neurobiology. Beyond academia, he advocates for public health, translating his research into practical solutions for improving human health.
In this episode, Dhru and Dr. Bryan dive into (audio version / Apple Subscriber version):
- Nitric oxide as the holy grail molecule (00:00:02 / 00:00:02 )
- Four hallmarks of disease (1:01 / 1:01 )
- Antacid medications: lack of research and the consequences of extended use (4:41 / 4:41 )
- Lower nitric oxide and the risk of Alzheimer’s (14:00 / 10:45 )
- Lifestyle habits that contribute to Alzheimer’s and biomarkers to check (17:15 /13:01 )
- What is nitric oxide and its core role in our bodies (27:00 / 23:39 )
- Lifestyle factors that hinder nitric oxide production (33:00 / 28:22 )
- Nitric oxide and high blood pressure (46:00 / 41:04 )
- Filtering water in your home and oral dysbiosis (51:00 / 46:30 )
- Navigating antacid medication usage and tapering off (1:11:00 / 1:06:50 )
- Testing nitric oxide level production (1:15:00 / 1:10:06 )
- The role of stress on our nitric oxide levels (1:29:00 / 1:24:53 )
- Foods that support production and supplementation (1:32:00 / 1:27:10 )
- Final thoughts: (1:44:00 / 1:39:40 )
Also mentioned in this episode:
N1O1.com (get 10% off any of Dr. Bryan’s nitric oxide products with the code DHRU)- Bryan Therapeutics
- EWG
- Fygg Toothpaste
For more on Dr. Bryan, follow him on Instagram, Twitter, YouTube, and through his website,
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Fatty15 is offering an additional 15% off its 90-day subscription Starter Kit. Go to fatty15.com/dhru and use code DHRU to replenish your C15 levels for long-term health.
To get 25% off your Birch Living mattress plus two free eco-rest pillows, head over to birchliving.com/dhru today.
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