Parkinson’s disease has long been defined by the death of neurons in the brain. Yet, decades before tremors appear, the first signs emerge quietly in the gut. Recent evidence reveals a puzzling disappearance: microbial pathways that once produced two well-known compounds fall silent. Their absence strips away protective metabolites, erodes the intestinal barrier, and leaves neurons exposed to toxins that ignite α-synuclein fibrils. Could the vanishing of two simple vitamins be an overlooked trigger, and a potential target, in the unfolding mystery of Parkinson’s disease?

00:00 Introduction to Parkinson's Disease

00:35 Early Signs and Gut Connection

01:19 The Braak Hypothesis and Vagus Nerve

02:08 Gut Microbiome and Vitamin Pathways

03:10 Global Meta-Analysis and Key Findings

04:37 Impact of Vitamin Deficiencies

08:57 Potential for Vitamin Supplementation

11:20 Conclusion and Future Implications

PMID: 37314861