The old "try lifestyle first" model for treating obesity is officially over. For years, we've treated obesity differently than other chronic diseases, often blaming a lack of willpower. In this podcast, I break down the new guidance from the American College of Cardiology and explore why we need to treat obesity as the complex biological disease it is, using powerful new medications synergistically with lifestyle changes right from the start.

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CHAPTERS:
00:00 - Intro
00:44 - The Scale of the Problem
02:21 - Diagnosing Obesity
05:19 - How Biology Affects Weight Loss
07:33 - How Lifestyle Only Tends to Fail
10:18 - A New Tool: Medications
11:32 - Effectiveness of Incretin Therapies
13:11 - The SELECT Trial
15:18 - Side Effects
18:24 - The ACC’s New Proposed Model
21:18 - Biggest Issues Preventing Change
23:22 - Takeaways
25:21 - Outro

SELECTED REFERENCES:
Gilbert, O., Gulati, M., Gluckman, T. J., Kittleson, M. M., Rikhi, R., Saseen, J. J., & Tchang, B. G. (2025). 2025 Concise Clinical Guidance: An ACC Expert Consensus Statement on Medical Weight Management for Optimization of Cardiovascular Health. Journal of the American College of Cardiology. [https://doi.org/10.1016/j.jacc.2025.05.024](https://doi.org/10.1016/j.jacc.2025.05.024)

*Disclaimer*

This podcast is for entertainment, education, and informational purposes only.
The topics discussed should not solely be used to diagnose, treat , or prevent any condition.
The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate.
Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.