What does it take to close the innovation gap in cardiology? Dr. Mohamad Alkhouli, professor of medicine and vice chair for strategic partnerships at Mayo Clinic, shares his perspective on AI, health span vs lifespan, and why structure drives behavior in healthcare.

This episode covers the future of multimodal AI, global innovation, and why doctors who embrace AI will lead the next generation of medicine.

Episode Breakdown

00:00 – Opening: AI as a personal coach and changing education

01:11 – Introducing Dr. Mohamad Alkhouli and Mayo Clinic Innovation Summit

03:01 – The innovation gap in cardiology explained

03:38 – Lifespan vs health span and the 11-year gap

04:11 – The cost of innovation and unsustainable healthcare spending

07:09 – Three main reasons behind the innovation gap

08:18 – Population-based models vs individual realities

09:04 – The problem with fragmentation in medicine

11:14 – Why grounding in pathophysiology matters

16:16 – From AI skepticism to embracing its role in decision-making

17:48 – Lessons from Waymo and the “extra eyes” analogy

20:29 – AI in code: new insights from old angiograms

22:28 – Multimodal AI and the future of cardiology diagnostics

25:27 – Why multimodal biomarkers will redefine disease classification

27:01 – How AI already improves procedural safety

28:02 – Mayo Clinic’s in-house AI models and the Mayo Clinic Platform

29:49 – Salience mapping and explainable AI

32:40 – AI in medical education and generational differences

36:18 – Redefining health: from WHO 1948 to dynamic health models

42:54 – Structure drives behavior in innovation and healthcare systems

45:20 – Democratizing innovation and involving frontline clinicians

48:06 – Why reimbursement and payer models matter for adoption

50:16 – ECG-based AI detection of aortic stenosis

52:09 – Pushback from payers and systemic barriers

55:38 – Value-based innovation and lessons from emerging economies

58:13 – Planning the next Mayo Clinic Innovation Summit

1:01:03 – The role of AI in connecting specialties and future training

1:02:25 – The Mayo AI Summit and opportunities to join

1:03:34 – Final thoughts: doctors who use AI vs doctors who don’t

1:04:22 – What’s in your AI stack? Omar and Dr. Alkhouli share their tools

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